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In contrast, a subsequent larger randomized controlled trial evaluating global non-motor outcomes including cognition, mood, and quality of life, did not find statistically significant overall improvements, suggesting that the benefits of GLP-1 agonists may be more domain-specific than generalizable across all non-motor symptoms [32]

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Researchers typically notice appetite suppression beginning within hours to days of their first dose

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A hot plate Ugo Basile, Italy, Model 7280 kept at 5456 C was used herein, on which the rats were placed

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