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Activation of MC4R in the central nervous system of rodent models has been studied in the context of energy balance research pathways

Phase I pharmacokinetic studies estimate parent-molecule oral bioavailability in the range of 4-16%

doi:10.1146/annurev-nutr-061121-084407 Jarrett H, McNulty H, Hughes CF, et al

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This conformation benefits the interaction of the thiazole group with the key residues Try7/111