Medications require refrigeration before first use, complicating travel
A 2022 randomized trial of exenatide did not meet its primary endpoint for reducing heavy drinking days in the overall population, though exploratory analyses suggested potential benefits in participants with obesity
Developed for optimal absorption and bioavailability
Without a strategy, GLP-1s could become a driver of runaway pharmacy costs in employer-sponsored health plans

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10.1016/j.neubiorev.2016.11.022 2 AkT.Glin