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[140] [141] Individuals who frequently self-administer high doses of amphetamine have a high risk of developing an amphetamine addiction, since chronic use at high doses gradually increases the level of accumbal FosB, a "molecular switch" and "master control protein" for addiction

adults reported smoking to about 12% in 2025, according to the Centers for Disease Control and Prevention

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The FY2026 tabular places four Excludes1 notes at the F17 category level: history of tobacco dependence (Z87.891), tobacco use NOS (Z72.0), tobacco use during pregnancy/childbirth/puerperium (O99.33-), and toxic effect of nicotine (T65.2-)