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The longest trials conducted on semaglutide have spanned two years

Saunders takes a similarly cautious strategy with her patients: When our patients are off medication for an extended period, we generally recommend starting back at the lowest dose and titrating up gradually. The more doses a person has missed, the more likely they are to have difficulty tolerating the medication when they restart it, and the more likely they are to have gastrointestinal side effects, Low Wang says

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Rather than aiming for a fixed amount like 64 ounces daily, patients should individualize fluid intake based on thirst, urine color (pale yellow indicates good hydration), climate, activity level, and medical conditions