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Pharmacologic options historically produced modest weight loss, were limited by tolerability or safety concerns, and rarely demonstrated improvement in hard cardiovascular endpoints

Rapp TL, Kopyeva I, Adhikari A, DeForest CA

Current NHS challenges: Demand for GLP-1 receptor agonists substantially exceeds supply, with many NHS areas implementing waiting lists or restrictive prescribing policies

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Senescent cells undergo profound epigenomic changes that distinguish them from both proliferating and quiescent cells ( In line with the mechanisms described above, recent studies on the epigenetic regulation of microglial senescence can be summarized as follows (Figure 5): global DNA hypomethylation (Cho et al., 2015