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Prior clinical studies questioned whether older RBCs are equally safe and effective as fresh RBCs, utilizing endpoints such as a multiple organ dysfunction score (MODS) [25], mortality [28] or other combinations of morbidity and mortality [29, 30]

But long-term treatment impairs their ability to bond as adults, a 2012 study found

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Department of Health and Human Services (HHS) told Healthline the FDA isnt at the point where it will declare an official shortage

Li S, Xia D, Prausnitz MR