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Levels also decline with age

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[PubMed] [Google Scholar] 111.Allameh A., Alikhani N

You will need to boost your B12 supply to address this situation

(Wikipedia) In senescent cells (cells that have permanently exited the cellcycle, accumulate damage, and secrete inflammatory factors), FOXO4 expression goes up and helps bind p53 in the nucleus, preventing p53 from driving those cells into apoptosis