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Mechanism semaglutide/tirzepatide: GLP-1 (and GIP) receptor agonism

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The standard adult dose is 500-1000mg every 4-6 hours, not exceeding 4g in 24 hours

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VPS35, a component of the retromer complex, contributes to mitochondrial fragmentation and impaired trafficking, particularly affecting dopaminergic neurons (Franco et al., 2021