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Adicionalmente, la sibutramina produce un aumento de la frecuencia cardiaca y la presin sangunea, que pueden ser clnicamente significativas en algunos pacientes, habindose registrado casos de arritmias, cardiopatas isqumicas y accidentes vasculares graves con su consumo

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[12] [13] Endogenous GLP-1 has a very short half-life, typically 12 minutes, as it is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4)

Senolytics focus on eliminating senescent cells, while senomorphics prevent the harmful extrinsic effects of senescent cells by selectively targeting and inhibiting the development of the SASP [98]

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