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Increased NFE2L2 activation, in turn, upregulates the synthesis of GSH, which detoxifies NAPQI, and hence protects against APAP hepatotoxicity
In summary, these experiments demonstrated that (i) GSH can replace the natural bound factor, (ii) that Cys-Gly (CG), the initial breakdown product of GSH 9 , also binds at the I site and (iii) that GSH binds more strongly than CG (Fig
The acid (where the bond to H breaks), the base (where the bond to H forms), the conjugate acid (the species that results when the base forms the new bond to H ) and the conjugate base (the species that results when the acid breaks its bond to H )
PubMed Gruchlik A, et al
10.1046/j.1471-4159.2001.00183.x 174 QualmanS
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