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182 In breast cancer, higher cysteine plasma concentrations are found in patients with higher body weight, 182,183 which is a known risk factor for breast cancer, progression and mortality, 184 further linking cysteine, metabolic dysregulation and cancer

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(2007) The relative contributions of insulin resistance and beta cell failure to the transition from normal to impaired glucose tolerance varies in different ethnic groups

Monitoring for when side effects typically appear after dose changes helps researchers distinguish expected transition effects from signals that warrant protocol modification