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Binding affinity studies demonstrate MT-2 exhibits significantly greater MC1R potency than native -MSH (Hadley & Dorr, Peptides, 2006)

The "reduced" version is the one you want in high supply

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J Clin Invest 2013;123:27302736.ArticlePubMedPMC 109

[PMC free article: PMC7214247] [PubMed: 32001810] 46

Although GLP-1 drugs typically suppress overall appetite, individuals may still notice: Sudden sweet cravings as nausea fluctuates Desire for reward foods or comforting rituals Emotional tension around eating and treats These experiences are common in community discussions and reflect how complex appetite regulation can be on GLP-1 therapy