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In addition, multinucleated cells (formed by cell fusion rather than division) can be formed in rats after administration of 2, 3, 7, 8-tetrachloro-dibenzo- p -dioxin (Gopinath, Prentice, and Lewis 1987

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10.1159/000354888 223 SinghT

A study in the International Journal of Exercise Science put this to the test

In addition, in cultured human tubular cells, cisplatin reduced SIRT3, resulting in mitochondrial fragmentation, while restoration of SIRT3 with ALC (200 or 500 mg/kg b.w., i.p .) improved cisplatin-induced mitochondrial dysfunction [102]