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In contrast, the D-amino acid Analogues 1.62 and 1.63 with D-cysteine or D-glutamic acid modifications lost detoxification efficacy from their interactions with GST

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[23,24,36] Pharmacodynamic and pharmacokinetic differences that occur with age are a second limitation, with variable responses in neonates, children and adults that result from maturation of developmental metabolic and transporter properties