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Symptoms often improve with time and dietary adjustments

The goals of GH therapy in PWS go beyond simply improving growth (119, 120)

Structural modelling further suggests that additional stabilising interactions strengthen and prolong IUB447GLP-1 receptor binding compared with native GLP-1, potentially explaining its superior efficacy

While this has been done in research settings, it is not practical for routine clinical therapy

Important precautions include: GLP-1 receptor agonists should not be used in patients with type 1 diabetes or diabetic ketoacidosis Caution is advised in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 These medications are not recommended in severe gastrointestinal disease They should not be used during pregnancy or breastfeeding, and semaglutide should be discontinued at least 2 months before a planned pregnancy [1] [7] Your GP or specialist will assess your individual circumstances to determine suitability

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