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There is a large set of requirements for barrier models: strong barrier function, the presence of a wide range of transporters and receptors, regulation of immune cell trafficking, mimicking a complex interaction of several types of cells, as well as, a dynamic balance between the cells

Therefore, a comprehensive exploration and assessment should be performed to elucidate the relation behind each mechanism

[2] Overall, the risk of death with SJS is 5 to 10%

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Beyotime Institute of Biotechnology, Shanghai, China) staining was used to detect the ROS generation in situ

BMC Med (2010) 8:54