When the cells are exposed to oxidative stress, NRF-2 escapes the negative regulation of KEAP1 through the increase of NRF-2, the transcription of interleukins decreases the levels of antioxidant response elements increase
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ROS can cause oxidative damage to lipid membranes by polyunsaturated fatty acids (PUFA), resulting in large amounts of lipid peroxides, which can lead to membrane damage and ferroptosis (ferroptosis) in intestinal epithelial cells (IECs) (4)