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Note that in addition to canonical (barrier-related) functions, zonulin and occludin have other key, noncanonical functions that allow them namely to regulate epithelial apoptosis and proliferation and to facilitate viral entry (124)

Neuro-Endocrinol Lett 30:4629 Aboul-Fotouh S (2013) Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats

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To date, although several drugs have been licensed as adjunctive therapies, the evidence of their effectiveness on clinically relevant outcomes other than blood glucose levels, such as cardiovascular and renal disease, is limited

2020;116 doi: 10.1016/j.msec.2020.111236