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During this time, women may experience unpredictable hormone shifts that can affect habits and overall metabolic health The hormonal shifts of perimenopause can make it harder to maintain your usual nutrition and exercise habits

MAPK, mitogen-activated protein kinase

Patients often describe feeling unusually tired, low on motivation, or physically sluggish during the early weeks of treatment

Common side effects include nausea, vomiting, diarrhea, constipation, and fatigue

I usually wait at least a week or two before adding the second medication, he says

doi:10.1016/S0893-133X(96)00055-3 [10] Stough C, Simpson T, Lomas J, et al