It is derived from several observations, including the inability of antibodies to minor populations of surface proteins for example, antibodies to NA on influenza viruses or to an altered conformation of the rabies G protein to neutralize the corresponding viruses owing to insufficient coating of virions
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Wharton S, Astrup A, Endahl L, Lean MEJ, Satylganova A, Skovgaard D, et al
Boddula, N.K
doi:10.1074/jbc.R100026200
They buy the first one, watch it perform for a year and then move to replace all their water level control systems with Waterline Controls units