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During the replication fork progression, TIMELESS forms a complex with TIPIN in the replisome to facilitate the progression of DNA replication fork 17,39,40

Focal brain injury is one of the major categories of TBI, and much research has focused on delineating changes in the mechanically injured cortex and penumbra zone, since this area increases significantly within hours after TBI due to edema, abnormal disrupted metabolism, inflammation, and subsequent cell death [53, 54]