Mutations in PDSS2, COQ6 , and ADCK4/COQ8B affect mainly the kidney by inducing steroid-resistant nephrotic syndrome while COQ2 mutations induce multisystem disorders whose severity correlates with the mutated genotype (Desbats et al., COQ4, COQ7, COQ9 , and/or PDSS1 develop encephalopathy and those affected by mutations in ADCK3/COQ8A develop mainly cerebellar disorders
(2019) reported that although the role of gut microbiota in IBS pathogenesis has been gradually elucidated, it remains unclear whether microbiota dysbiosis is a cause of IBS
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Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease
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