In the SURMOUNT-1 clinical trial published in the New England Journal of Medicine, participants on the 5 mg dose achieved an average weight loss of 16% of body weight over 72 weeks
Do not discontinue the medication without medical guidance, as abrupt cessation could adversely affect your diabetes control or weight management goals
Clinical trials (SURPASS programme) have demonstrated that participants achieved significant reductions in HbA1c levels and body weight compared to other diabetes medications and placebo
One of the most appealing aspects of Mounjaro is its convenient dosing schedule
By 5 mg, the sustained signal approaches the peak produced by a large meal. In diabetes trials, every dose improved insulin sensitivity while reducing the amount of insulin needed. GIP also activates an anti-nausea circuit in the brainstem, which helps offset some of the gastrointestinal burden created by GLP-1. GLP-1R: appetite, tolerability, and heart rate The GLP-1 arm carries appetite suppression, slower stomach emptying, most nausea, and part of the heart-rate signal
In the UK, Wegovy is authorised for weight management and can be prescribed privately following an appropriate clinical assessment
