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Bupropion ignores serotonin almost entirely and instead focuses on two other neurotransmitters that play critical roles in mood, motivation, and energy: dopamine and norepinephrine

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The real divergence sits deeper: in molecular architecture, in the physical pocket each ligand occupies, in the signaling bias each produces, in pharmacokinetics, and crucially for anyone designing a preclinical study in a species-specificity quirk that quietly invalidates the ordinary rodent model

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