does glp-1 cause heartburn Acid Reflux? Evidence and Management GERD and GLP-1 Medications |

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(168) showed that mice with histone deacetylase 3 (HDAC3) knockout in IECs were resistant to diet-induced obesity and showed improved glucose and lipid metabolism compared to wild-type mice, which may be due to increased energy expenditure, heat production and oxygen consumption (168)

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The results of this study support the hypothesis that SGLT2i and GLP1-ra may have a beneficial role in preventing the development of DMO in individuals with type 2 diabetes taking insulin, but due to the study design they do not establish a causal link