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Side effects are almost always worst during dose titration, when the medication is ramped up every 4 weeks

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Understanding Semaglutide and Its Mechanism Semaglutide is a GLP-1 receptor agonist, which works by mimicking the action of the glucagon-like peptide-1 hormone

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These include CACNA1C, the NMDA receptor (NMDAR), and the G q -protein-coupled serotonin and ghrelin receptors [34]