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10.5582/irdr.2020.01007 5 AlgahtaniH.ShirahB.AlgahtanyM.AlqahtaniS.AbdelghaffarN

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Molecular mechanisms of ferroptosis and its role in viral pathogenesis

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Together, these findings suggest that cellular resistance to cuproptosis also depends on a hierarchically organized copper-buffering system, in which mtGSH provides rapid, dynamic metal buffering, whereas metallothioneins confer sustained high-affinity sequestration to prevent mitochondrial copper overload