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2023;10.1002/ oby.23859
Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells
For instance, glutathione peroxidase 4 (GPX4), a core regulatory gene involved in ferroptosis, is negatively associated with the prognosis of breast cancer, as its expression enhances ferroptosis in cells (9)
The challenge and opportunity lie in harnessing these membrane proteins with precision, possibly through multi-component nutraceuticals like cinnamon, which may achieve a balanced modulation of pathways due to its polypharmacology across different targets
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