Diabetes , 12 , 916931
Baseline characteristics for the 20 randomized and exposed participants are presented in Table S2
In particular, the suboptimal pharmacokinetics and pharmacodynamics of these compounds and their poor ability to cross the BBB could represent considerable obstacles for a significant therapeutic efficacy
Garca-Gutirrez MS, Navarrete F, Gasparyan A, Austrich-Olivares A, Sala F, Manzanares J
1 Patients with anxiety disorders also frequently have depressive disorders or bipolar disorder
The European Medicines Agencys 2025 synthetic peptide quality guideline treats peptide-related impurities as first-class critical quality attributes: deletion and truncated sequences, dimers, oligomers, and degradation products each need characterization, with European Pharmacopoeia practice pointing to reporting thresholds at 0.1% and identification thresholds above 0.5% for peptide-related impurities in pharmaceutical use