10.1016/j.heares.2009.03.001 44 OwensK
More than 90% of dietary TRP is metabolized via the KP, primarily in the liver [171], generating circulating KYN that readily crosses the BBB, whereas downstream metabolites such as KYNA, QA, and 3-HAA remain largely trapped within the CNS once synthesized [20]
Therefore, the mitochondrial NADH generated by fatty acid beta-oxidation and the cytoplasmic NADPH preserved from inhibition of fatty acid synthesis during fasting may contribute to the reductive redox shift that occurs
The relationship between trinucleotide (CAG) repeat length and clinical features of Huntingtons disease
Those with copper metabolism disorders, kidney disease, or taking copper-sensitive medications should consult a provider first
Decide with your doctor after weighing both benefits and risks for your specific condition