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Accusations against the manufacturer include that they knew of the increased risk for adverse health issues, especially with long-term use, and failed to adequately warn consumers

(1994) with the possible exception of Phe- 12 (substitution to Ala resulted in 133-fold reduced affinity and 13-fold reduced potency), although the larger Tyr side chain in the Xenopus sequence is likely to be a more acceptable substitution compared with Ala

You have tried a non-GLP-1 medication for diabetes, such as metformin

However, there was a decline in efficacy over subsequent months

It is important that you fully read the information given to you by your doctor and seek answers to any questions or concerns

2013 Jun;88(6):544-51