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The evidence behind the semaglutide molecule Whether branded or compounded, the semaglutide molecule's weight-management evidence traces mainly to the STEP trial program in The New England Journal of Medicine (2021)

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Additionally, it is worth mentioning that the product is also actively studied when it comes to other indications, such as the reduction of knee osteoarthritis pain

It increases insulin release when high glucose levels and reduces the livers sugar production

Recent studies have uncovered increased DPP-4 expression and secretion from hepatocytes in obese mice, with a DPP-4 expression and activity much higher in the liver than in adipose tissue, indicating its emerging role as a hepatokine in the interplay between hepatocytes and adipocytes [4]