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Moreover, a 7.5% (58 mmol/mol) intensification threshold was tested in a sensitivity analysis, leading to more positive results for oral semaglutide and demonstrating the 8.0% (64 mmol/mol) threshold as a conservative assumption (Fig

That alone tells you this is not a single, cause issue

Supplementary information Additional file 1:

Results tend to be most impressive for acute soft tissue injuries less than 6 months old, while chronic structural damage may respond more slowly or incompletely

In parallel, in-depth mechanistic studies could identify the precise biological mechanisms underlying the association between ACs and depression

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