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To enable the discovery of novel GLP-1R G-protein-biased agonists displaying selectivity and high potency for the GLP-1R, combinatorial peptide libraries were designed based on the competitive GLP-1R antagonist Ex 939 sequence to which 710 random amino acids have been added to the N terminus

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Regul Pept 134(23):149157 Higa-Sansone G, Szomstein S, Soto F, Brasecsco O, Cohen C, Rosenthal RJ (2004) Psoriasis remission after laparoscopic Roux-en-Y gastric bypass for morbid obesity