For a broader context on medicines and body weight, see Diabetes Medications Cause Weight Loss for mechanisms and expectations
Options include: Other GLP-1 receptor agonists (such as semaglutide or dulaglutide), though these share similar mechanisms and side effect profiles SGLT2 inhibitors (such as dapagliflozin or empagliflozin), which work through different mechanisms and have cardiovascular and renal benefits DPP-4 inhibitors (such as sitagliptin), which have a more modest effect on glycaemic control and weight Metformin (if not already prescribed), which remains the first-line treatment for type 2 diabetes according to NICE guidelines Insulin therapy (for patients requiring more intensive glycaemic control) For weight management specifically , alternatives to tirzepatide (Zepbound) include semaglutide 2.4 mg (Wegovy), which is approved by NICE for managing overweight and obesity, orlistat, or comprehensive lifestyle intervention programmes
Fitz, V., Graca, S., Mahalingaiah, S., Liu, J., Lai, L., Butt, A., Armour, M., Rao, V., Naidoo, D., Maunder, A., et al
Transporting fatty acids into mitochondria to generate energy improves stamina and endurance
FDA Drug Shortages Database
Annual initiation prevalence was calculated for each eligible BMI subgroup