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It appears to be a convention that emerged from the research-chemical market, not from the literature

Acta Neuropsychiatr 2020;32:313-20

Reducing your intake of these substances can help maintain optimal antioxidant levels

Environ Sci Pollut Res 16 , 206213 (2009)

TB-500 shares a similarly clean safety profile, though theoretical concerns exist regarding its pro-angiogenic and cell-migration properties in the context of existing tumors direct tumorigenic evidence is lacking, but researchers working with tumor models should note the potential interaction

Comprehensive toxicology evaluation revealed no lethal dose in rats receiving up to 20 mg/kg intramuscularly with 14-day observation