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*Patients without diabetes and with BMI 30, or BMI 27 plus a weight-related condition, lost an average of 15% of their body weight in 1 year, when paired with healthy lifestyle changes (compared to 2.4% with diet and exercise alone)

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Protein kinases exhibit distinct and highly specific consensus binding motifs that dictate their enzymatic phosphorylation activity

A 12-week phase II placebo-controlled clinical trial with 255 patients with type 2 diabetes receiving KBP-042 has been completed (156), but further development of KBP-042 has been terminated by Eli Lilly and Nordic Bioscience to focus on the development of KBP-089, which is reportedly superior to KBP-042 (157, 158)