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DOI: Roman, G

Clin Pharmacokinet 65 , 10871099 (2026)

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Reactive oxygen and nitrogen species are generated by activated microglia, infiltrating macrophages, and dysfunctional mitochondria within inflammatory lesions, where they contribute to demyelination, axonal injury, and neurodegeneration ( Pharmacokinetic constraints remain a major barrier to the clinical translation of antioxidant therapies in MS

According to the CIRS diagnostic framework, approximately 24% of the population carries specific HLA-DR genetic variations that prevent their immune systems from properly identifying and eliminating biotoxins