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Pesquisas indicam que, embora alguns desses medicamentos tenham dificuldade em atravessar a barreira hematoenceflica, h evidncias de que certos anlogos como o exenatida conseguem atingir regies profundas do crebro, como o hipocampo, rea frequentemente afetada nos estgios iniciais do Alzheimer

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doi: 10.1016/j.biochi.2016.10.020 70 ClarkTCTinsleyJSigholtTMacqueenDJMartinSAM

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