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Mechanism and Catalytic Strategy of the Prokaryotic-Specific GTP Cyclohydrolase-IB

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Key findings include: A 2004 study by Khavinson and colleagues showed that Epitalon enabled human fibroblasts to exceed the Hayflick limit and complete additional cell divisions direct evidence of telomere-mediated lifespan extension in human cells.3 A 2025 independent study by Al-Dulaimi and colleagues in Biogerontology confirmed that Epitalon extends telomere length via telomerase upregulation in human cell lines the first major independent replication outside Khavinson's laboratory.4 A 2003 animal study by Anisimov and colleagues showed Epitalon extended lifespan and reduced spontaneous tumor incidence in SHR mice.5 A 2025 retinal cell study found that Epitalon improved wound healing under high-glucose conditions, reduced reactive oxygen species, and improved antioxidant gene expression.6 Beyond telomeres, Epitalon modulates pineal gland function and melatonin synthesis relevant to circadian regulation, sleep architecture, and the broader neuroendocrine decline associated with aging

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