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Co-IP Procedure (using endogenous Co-IP as an example) Sample Preparation: Collect cells using an appropriate method and lyse them with Lysis Buffer containing suitable protease inhibitor cocktail to preserve protein-protein interactions

12 weeks 2 x 10 mL bottles 3 vials use 9 mL total

Coffee enema with PEG group A split dose of PEG (1 L of the total 2-L dose) was administered before and after the coffee enema

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Retatrutide stability at various pH levels has not been extensively characterized in the public literature

With clinical trials ongoing, phase 3 results arrive in 2026, guiding future treatment guidelines and potentially FDA approval