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We also performed mitochondrial morphology assessments in dispersed islet cells from mice transfected with Control versus SPHKAP siRNA, which responded similarly to intact islets in terms of increased mitochondrial fragmentation following exendin-4 exposure in control conditions, but showed disturbed mitochondrial morphology under vehicle conditions and no further effect of exendin-4 exposure in SPHKAP siRNA-treated cells (Fig

Therefore, in these types of cancer vitamin K may be contraindicated

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