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PEGylated exendin-4, a modified GLP-1 analog exhibits more potent cardioprotection than its unmodified parent molecule on a dose to dose basis in a murine model of myocardial infarction

In humans, a landmark 2023 observational study of over 80,000 patients with obesity found that those on semaglutide had a 50-56% lower incidence of alcohol use disorder compared to patients on other anti-obesity medications

doi: 10.1016/j.healun.2004.10.013

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They were all large-scale trials involving 3,000 to 18,000 patients who were either at high risk of or having established ASCVD, with trial durations ranging from 15 to 60 months