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In clinicaltrials of Ozempic and Wegovy, nausea was reported in: 15.8 percent of those taking a 0.5 milligram (mg) dose of semaglutide 20.3 percent of those taking a 1 mg dose 44 percent of those taking a 2.4 mg dose These were all semaglutide injections, but nausea is also the most common side effect of Rybelsus, a semaglutide tablet

Insomnia was not among the most prominently reported adverse events in that dataset, though the full adverse event profile across all ongoing trials continues to be collected and assessed

The Journal of Clinical Investigation, 79 (2), 616619