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Age at index was defined by TriNetX as the age on the index date, and the 18-year filter was applied at cohort creation

For patients who already have an existing GLP-1 prescription and are not changing their dose, Amazon offers a separate on-demand telehealth renewal pathway that operates independently of the full GLP-1 Management Program

Hypersensitivity reactions may manifest in various ways, ranging from local injection site reactions such as erythema, swelling, and pruritus to more severe systemic reactions including angioedema, anaphylaxis, or generalized urticaria

Bypasses the Gastrointestinal System: Peptide nasal sprays may have higher bioavailability than capsules because they bypass the human digestive system

Each vial undergoes stringent quality control tests including purity, pH, sterility, and pyrogen testing

Manuja et al., 2021)