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37 ChhabraR.SahaA.ChamaniA.SchneiderN.ShahR.NanjundanM

This inflammation reaches the systemic level and, subsequently, the central nervous system (CNS), which can lead to oxidative stress and mitochondrial dysfunction, resulting in brain damage

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This localization is directly related to the key role of Tau in the maintenance of the complex architecture of the neuron by stabilization of microtubule (MT) bundles through interactions with tubulin subunits (Avila et al., 2004)