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[DOI] [PubMed] [Google Scholar] 6.Munier-Lehmann H., Lucas-Hourani M., Guillou S., Helynck O., Zanghi G., Noel A., Tangy F., Vidalain P.-O., Janin Y.L

Autosomal recessive PARK2 mutations, a leading cause of early-onset PD, reduce or eliminate Parkin, impairing mitophagy, causing damaged mitochondria to accumulate, increasing oxidative stress, and triggering dopaminergic neuron death, thus driving PD progression (143)