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Crucially, the structure incorporates a C20 fatty diacid moiety that facilitates albumin binding in laboratory models, protecting the peptide from immediate enzymatic cleavage and extending its reported half-life to approximately 6 days

All statistical analyses were conducted using R software (version 4.2.3, R Foundation for Statistical Computing, Vienna, Austria)

Sikiric P, Seiwerth S, Rucman R, Turkovic B, Rokotov DS, Brcic L, Sever M

Important safety note: The FDA advises against using quinine or quinine-containing products (including tonic water) for leg cramps due to serious safety concerns

If a PRO-PM is developed and included in ASM, we would indicate it in advance via notice-and-comment rulemaking and would ensure there is adequate time for the survey(s) to be implemented