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The elevated reactive oxygen species (ROS) disrupt insulin receptor signaling and stimulate the release of pro-inflammatory cytokines, thereby worsening metabolic imbalance

Competing interests AT has no financial interests to disclose related to this manuscript

These modifications preserve the peptides structural integrity, extending its half-life to approximately 30 minutes

Chronic neuroinflammation, oxidative stress, and impaired glucose metabolism in the brain are also recognized as contributing factors to disease pathogenesis